Main Street Inn Bed & Breakfast

10 Guest Rooms • Full Gourmet Breakfast • Weekday Specials

Welcome to Ste. Genevieve’s Timeless Treasure

Located in the heart of Missouri’s oldest permanent settlement, the Main Street Inn Bed & Breakfast offers a perfect blend of historic charm and modern comfort. Originally built in 1882 as the Meyer Hotel, this beautifully restored 3-story brick landmark has been lovingly renovated by owners Patrick Fahey and Susan O’Donnell. Each of the 10 unique guest rooms features private en-suite bathrooms, elegant furnishings, original art, and antique details.Enjoy daily wine & cheese receptions, a delicious full breakfast, and the warm hospitality that makes guests return again and again. Just steps away from the Ste. Genevieve Antique Mall and surrounded by historic homes, shops, and restaurants.

Elegant Historic Rooms

10 unique guest rooms and suites, each with its own character and private en-suite bathroom. Step back in time while enjoying modern comforts. All rooms feature luxurious bedding, antique furnishings, original artwork, high-speed WiFi, and thoughtful details. Several rooms include king beds, sitting areas, and pet-friendly options.

Gourmet Breakfast

Wake up to fresh coffee, homemade pastries, seasonal fruit, and a rotating menu of hearty favorites made with local ingredients. Breakfast is served in our beautiful dining room or on the porch when weather permits.

Art & Culture

The Main Street Inn features an impressive collection of contemporary and regional art, including works by Shepard Fairey, Bryan Haynes, and local artists, plus rare Frank Lloyd Wright Garden Sprites in the courtyard.

Relax on the Porch

Sit and rock in comfortable chairs overlooking historic North Main Street. A perfect place to enjoy your morning coffee, evening wine & cheese reception, or simply watch the world go by.

Steps from Everything

Just a short walk to the Ste. Genevieve Antique Mall, Missouri’s oldest church, the National Historical Park, great restaurants, shops, and riverfront attractions. No need to move your car once you arrive.

Why Guests Love Main Street Inn

10 Beautiful Rooms

Private baths, luxurious linens, and unique antique décor in every room

Each room is thoughtfully decorated with a mix of antique furniture, original artwork, and modern comforts like plush bedding and updated bathrooms. Guests particularly love the high ceilings, tall windows with natural light, and the personalized touches that make every stay feel special and memorable. Wake up refreshed and ready to explore.

Full Gourmet Breakfast

Included daily — made from scratch with local ingredients

Breakfast is prepared fresh each morning using quality ingredients, often featuring local Missouri products. The menu changes daily and is served in the elegant dining room or on the sunny front porch, creating a wonderful start to your day in historic Ste. Genevieve. Enjoy a quiet moment before the day starts or converse with fellow travelers.

Wine & Cheese Reception

Complimentary evening gathering for guests

Guests are warmly invited to the elegant North Parlor for a relaxing selection of wines, cheeses, and light appetizers while getting to know fellow travelers and the innkeepers. It’s the perfect way to unwind after a day of exploring the Antique Mall and historic sites, often sparking great conversations that continue over breakfast the next morning.

Art Collection

Works by nationally known artists throughout the inn

The Main Street Inn proudly displays an impressive collection of contemporary works alongside regional pieces, including originals by Shepard Fairey and Bryan Haynes. Guests can also enjoy the peaceful courtyard featuring rare Frank Lloyd Wright Garden Sprites sculptures. Our community spaces invite you to relax and browse the works.

Pet Friendly

Select rooms welcome well-behaved dogs

These pet-friendly accommodations feature easy outside access so your dog can come and go without disturbing other guests. You’ll also enjoy the same luxurious linens, antique details, and modern comforts as our other rooms, plus plenty of nearby walking paths along the historic streets for daily strolls with your furry companion.

Unbeatable Location

Walking distance to Antique Mall, shops, dining & attractions

You can easily walk to the Ste. Genevieve Antique Mall, charming shops, excellent restaurants, museums, and the Mississippi Riverfront. Many guests leave their car parked for the entire stay and enjoy exploring everything the historic district has to offer on foot. Ask us for directions to any of the local attractions.